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Research Laboratories & Centers

Organic and Biocatalytic Chemistry


Professor SUGAI

Professor: SUGAI Takeshi

Associate Professor: HIGASHIBAYASHI Shuhei

Senior Assistant Professor: HANAYA Kengo

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Human body is made of various types of optically active molecules and functions through their mutual interactions. Therefore, a majority of drug molecules have to be optically active and enantioselective synthesis is an essential tool in the research of new drug discovery, and sometimes, is vital.

Our research activity focuses on the synthesis of enantioselective molecules applicable as pharmaceuticals using both organic and enzymatic chemistry as two major research tools


Currently four topics are extensively studied;

1) Integrated chemo-enzymatic synthesis (three lab staffs)

Taking advantages of the combining application of enzyme-catalyzed enantiomeric resolution, asymmetric synthesis and other biotransformations, expeditious synthetic routes of oseltamivir derivatives, macrocyclic lactones, pharmaceutial targets & manufacting intermediates have been developed.

2) Total synthesis of bioactive natural products (Shoji, M.)

New stereo- and chemoselective reactions involving cycloaddition and organocatalyst-mediated functionalization were developed for total synthesis of batrachotoxin and epoxyquinols, carnosic acid, etc.

3) Synthetic and biological studies of aromatic bioactive materials (three lab staffs)

Regio- and stereoselective chemical and biochemical transformation were applied to provide new derivatives of phenolic substances, such as resveratrol, dephostatin and TBMB acids.

4) Enzyme-mediated synthesis of carbohydrates (Sugai, T.)

New pathways for the synthesis of various carbohydrates were developed using inexpensive and abundantly available compounds as starting materials, and by the application of chemo-enzymatic reactions. Carbohydrates so far synthesized are sugers (L-nucleosides, etc.), deoxyamino sugars and their derivatives (D-ManNAc, zanamivir-related sialic acids), and oligosaccharides, such as LeX.

Graduates of our laboratory will be fascinated by synthetic study through acquiring vast and deep knowledge and skill about organic and enzymatic chemistry.
They will have the potential to be medicinal and/or process chemists in pharmaceutical industry, and also be researchers and manufactures in chemical, petroleum and food industries, and in academic fields industries, and in academic fields.

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Natural Medicines


Professor KIKUCHI

Professor: KIKUCHI Haruhisa

Senior Assistant Professor: NARUKAWA Yuji

Assistant Professor: UEKUSA Yoshinori

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Exploitation of New Natural Resources for Drug Discovery

Outline

Humans have been using plants, mushrooms, and other organisms as medicines since ancient times. In fact, many medicines have been developed from natural compounds produced by plants, fungi, bacteria, and other microorganisms. Thus, natural compounds are the resources for drug discovery.

We conduct research to find natural product that can be used as resources for drug discovery, or to create them using natural compounds as motifs. In addition, we aim to use the substances obtained as seed compounds for the development of pharmaceuticals, as well as for the development of substances useful for life science research.

On the other hand, as a result of the vigorous search for natural compounds, new natural compounds are being depleted. Therefore, it is not possible to conduct innovative drug discovery research by simply searching for natural compounds in the conventional way. Therefore, we will actively explore new resources for drug discovery.

  1. Exploitation of new resources for drug discovery using diversity-oriented synthesis
    Diversity-oriented synthesis is a synthetic method for producing a large number of compounds with different molecular skeletons from a single starting material. In particular, "diversity-enhanced extracts," which combine diversity-oriented synthesis with search for natural compounds, can yield a group of new compounds with structural diversity that exceeds that of natural compounds obtained from plants and microorganisms. We will conduct research to utilize these compounds as resources for drug discovery.
    For example, we will perform chemical reactions directly on the extracts of medicinal plants used as crude drugs, as used in diversity-directed synthesis, to produce diversity-enhanced extracts. By separating, purifying, and structurally determining these extracts, we can construct a library of structurally diverse compounds and obtain seed compounds for drug discovery research.

  2. Development of new resources for drug discovery using unexploited organisms
    As a new drug discovery resource, we will focus on " unexploited organisms" which are different from conventionally used organisms, such as plants, fungi, and bacteria, for the search of natural compounds. Particularly, we will focus on protists, which are extremely diverse organisms that span multiple biological kingdoms, and utilize unexploited organisms such as cellular slime mold, oomycetes, and pelagic algae. In fact, compounds obtained from cellular slime mold have been developed as commercially available reagents for life science research. Thus, these unexploited organisms, including cellular slime mold, are considered to have great potential as new resources for drug discovery.

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Molecular Design


Professor KUMAGAI

Professor: KUMAGAI Naoya

Associate Professor: OHE Tomoyuki

Project Senior Assistant Professor: YASUDA Daisuke

Project Assistant Professor: TSUTSUMI Ryosuke

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Design, Synthesis, and Application of Novel Functional Heterocyclic Compounds

DATB (1,3-Dioxa-5-Aza-2,4,6-TriBorinane), a peculiar six-membered heterocyclic entity without any carbon atoms designed by our group, strongly catalyzes amide bond-forming reactions from carboxylic acids and amines. In contrast to reagent-driven amidation reactions that produce reagent-derived waste, water is the sole by-product in the environmentally sustainable DATB catalysis, which will find its utility in the large-scale production of amide-containing therapeutics. DATB is a thermally stable solid and is now commercially available on a world-wide basis. We aim to further explore DATB catalysis and design/development of novel heterocyclic entities for as-yet unknown molecular functions.

Design, Synthesis, and Application of Concatenated Azoles with iconic Structures

TriQuinoline (TQ) is a head-to-tail quinoline trimer with a pseudo-planar architecture, bearing a one-atomic size defect at the very center of the molecule. TQ strongly holds a proton at the defect to be a charged species, acquiring water-solubility despite its expected lipophilicity. TQ forms supramolecular complexes with other aromatic compounds via both π-π(face to face)and CH-π(edge to face)interactions, allowing for inhibitory effects on cancer cell proliferation and modulation of lipid-lipid phase separation in live cells. The flexible derivatization capability of TQ will be leveraged to identify a new class of functional and bioactive azole-type molecules. Current works are focused on the design and synthesis of a larger three-dimensional architecture to expand the potential of these azole-based molecular entities.

C4N4 Fluorophore

We have identified a new class of fluorescent molecules named C4N4 with a diaminopyrimidine core composed of four carbon and nitrogen atoms. C4N4 fluorescent molecules can be synthesized from commercially available chemicals in a modular fashion, producing strongly luminescent molecules with a large Stokes shift and a solid state emission capability applicable to live-cell bioimaging. We are currently pursuing strategic structural modifications to develop a more sophisticated fluorescent host composed of C4N4 units able to sense specific guest molecules for application as novel CPL molecules.

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Hygienic Chemistry


Professor TAGO

Professor: TAGO Megumi

Senior Assistant Professor: NAKAZAWA Yosuke

Assistant Professor: UEDA Fumihito

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"Investigation of the molecular basis for prevention of lifestyle-related diseases through the food"

Prevention of lifestyle-related diseases such as obesity, hyperlipidemia, arteriosclerosis, diabetes, and hypertension is a urgent issue for the public health of our nation. Aiming at the prevention of lifestyle-related diseases through diet, we are carried out to research from various angles.

    1. Prevention of lifestyle-related diseases through effects of foods on the metabolism of steroids.
      Steroid hormones such as estrogens and glucocorticoids, have a variety of physiological activity, and their activities are known to correlate with the risk of developing a variety of lifestyle-related diseases. On the other hand, it has been well recognized that diet has a significant impact on prevention and risk of developing lifestyle-related diseases. There are various reports which show correlation between the effects on prevention of lifestyle-related diseases and the effects on steroid metabolism by food ingredients. In recent years, epidemiological studies showed that coffee has preventive effect against a variety of lifestyle-related diseases, including cancer and diabetes. Then, we are evaluating the effect of coffee on the steroid hormone metabolism.
    2. Analysis of the molecular basis of the effects of probiotics on the lifestyle-related diseases.
      Epidemiological studies indicate that there is a habitual intake effect of bifidobacteria and lactobacteria contained in yogurt to prevent lifestyle-related diseases, such as cancer and hyperlipidemia and inflammatory gastrointestinal disease. Using cultured cells derived from human gastrointestinal tract, we have analyzed the effects of probiotics on the immune system and cholesterol absorption within the digestive tracts.

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Biochemistry


Professor HASE

Professor: HASE Koji

Associate Professor: KIMURA Shunsuke

Senior Assistant Professor: TAKAHASHI Daisuke

Project Senior Assistant Professor: OHASHI Wakana

Project Assistant Professor: NAKAMURA Yutaka

Project Assistant Professor: YAMADA Takahiro

Project Assistant Professor: SEKI Natsumi

Lab Homepage外部リンク

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Humans harbor over 100 trillion bacteria in the distal intestine. These commensal bacteria have long been appreciated for the benefits they provide to the host, the most obvious being their capacity to metabolize indigestible food components to small metabolites that are utilized as nutrients by host cells. Moreover, it is now clear that the presence of commensal bacteria contributes to shape the gut immune system though promoting the development of gut-associated lymphoid tissues (GALTs), the largest collection of secondary lymphoid organs, which are necessary for induction of mucosal IgA responses. To evoke the mucosal immune response, antigens on the mucosal surface must be transported across the epithelial barrier into GALT such as Peyer's patches. This function, called 'antigen transcytosis', is mediated by specialized epithelial M cells. We are currently conducting the studies to understand the molecular machinery by which intestinal M cells facilitate antigen transcytosis.

Certain enteric bacteria also facilitate differentiation of Th17 and Treg cells, both of which are major T cell populations in the intestinal mucosa. Thus, host-microbe interactions establish immunological homeostasis in the gut, which further raises the important question: how do commensal bacteria affect the host immune system? The intestinal microbiota constitutes a considerable bioreactor that ferments indigestible food substances (e.g., soluble dietary fibers and resistant starches) into various metabolites such as short-chain fatty acids (SCFAs). Notably, butyrate, a major SCFA, exert histone deacetylase (HDAC) inhibitory activity. We have shown that intestinal microbiota-derived butyrate contributes to establishing intestinal symbiosis by inducing Treg cells via the epigenetic mechanisms. Our laboratory aims to explore the epigenetic regulation of the immune system by intestinal microbiota, and also to elucidate the biological significance of this epigenetic regulation in immunity and metabolism.

Key publications:
Kimura I. et al., Science 367: eaaw8429, 2020.
Nagai M. et al., Cell 178: 1072-1087, 2019.
Furusawa Y. et al., Nature 504: 446-450, 2013.

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Physics for Life Functions


Professor OSAWA

Professor: OSAWA Masanori

Senior Assistant Professor: YOKOGAWA Mariko

Assistant Professor: HARADA Ayaka

Project Associate Professor: IKEDA Kazuyoshi

Project Assistant Professor: SHIMIZU Yugo

Project Assistant Professor: BAO Yu

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Our research objectives are: (1) to reveal structural mechanisms of proteins critical for life functions at atomic level, (2) to establish novel strategies for drug developments based on the mechanisms, and (3) to create compounds to regulate the life functions. Proteins playing important roles physiological processes are analyzed at an atomic resolution by nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography.

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Pharmacology


Professor MISAWA

Professor: MISAWA Hidemi

Associate Professor: OKUDA Takashi

Senior Assistant Professor: MORIWAKI Yasuhiro

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The major focus of this laboratory is a disease-oriented basic neuroscience research. Although recent progress in the neuroscience field begins to shed light on complicated interactions between genetic and epi-genetic (environmental) control in the nervous system, fundamental brain functions such as learning/memory, attention, sleep, movement control are largely still enigmatic. Neurodegenerative diseases are adult-onset and slowly progressive disorders affecting the central and peripheral nervous system. One of the major causes of the diseases is known to be aging. With the growth of elderly population, risks of suffering from these diseases are rapidly increasing and making them heavy social burden.
The main goals of our research are to elucidate physiological and pathological roles of cholinergic neurons in neurologic/psychiatric diseases such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and schizophrenia, and ultimately develop better pharmacological interventions to these devastating conditions.
We are looking forward to working with motivated students who have high interest in basic research for uncovering hidden mysteries of brain functions and their disorders.

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Physiological Chemistry and Metabolism


Professor ARITA

Professor: ARITA Makoto

Assistant Professor: NAGANUMA Tatsuro

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Chemotherapy


Professor SUGIMOTO

Professor: SUGIMOTO Yoshikazu

Assistant Professor: KONDO Shingo

Assistant Professor: KATO Yu

Recent advance in molecular biology of cancer has provided the rationale for the control of cancer. Our research is focused on molecular target therapy of cancer, anticancer drug resistance, gene therapy and regenerative medicine. Particularly, we have been studying functional interactions between the ABC transporter proteins, molecular-target drugs and genetic polymorphisms to contribute to the understanding of the molecular basis of the pharmacokinetics of currently used anticancer drugs and to provide valuable information to optimize the effectiveness of novel chemotherapeutics. We are also investigating molecular basis of cancer malignancy to identify novel molecular targets for anticancer agents. Collaborative studies between our laboratory and major pharmaceutical companies are ongoing for the development of new anticancer agents. All laboratory members actively conduct the forefront research of cancer treatment.

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Analytical Chemistry for Drug Discovery


Professor HANAOKA

Professor: HANAOKA Kenjiro

Associate Professor: NAGASE Kenichi

Senior Assistant Professor: ITOH Yoshiko

Project Professor: KANAZAWA Hideko

Project Senior Assistant Professor: SASAKI Eita

Project Assistant Professor: YAMADA Sota

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In the analysis of biological phenomena and pathology, "smart molecules" having special functions enable the visualization and control of biological phenomena, which have never been achieved by conventional methods. These molecules exhibit various abilities in biological samples by precisely designing the molecular structures. The objective of our laboratory is to develop new functional molecules which can be applicable in pharmaceutical research. We design and synthesize these functional molecules, and apply them to molecular imaging, drug discovery, drug delivery system (DDS), bio-separation and bio-analysis.

Activatable Fluorescent Probes Based on Novel Fluorophores:

We precisely designed and chemically synthesized activatable fluorescent probes, which can show the fluorescent spectral change in response to the specific biomolecules, based on our novel fluorophores (Angew. Chem. Int. Ed. 2020, 59, 6015. J. Am. Chem. Soc. 2018, 140, 5925. J. Am. Chem. Soc. 2017, 139, 13713, etc.). By using these probes, the dynamics of biomolecules in biological systems can be visualized. Our goal is to apply these probes to the fluorescence imaging of biosamples and realize the biological phenomena.

Self-assembling Designer Proteins:

We genetically and chemically engineer self-assembling proteins to create designer protein shells which serve as molecular containers for storage, delivery and production of bioactive materials (Nat. Commun. 2017, 8, 14663. ChemBioChem 2020, 21, 74-79.). Our goal is to apply such functional protein shells to drug delivery systems and molecular sensors to analyze and control various biological phenomena.

Purification of Biopharmaceutical and Cells using Functional Polymer:

We are developing innovative purification system for biopharmaceuticals and therapeutic cells using functional polymers. The system can purify antibody drugs and stem cells with maintaining their activity and low cost (Anal Chim Acta. 2020, 1095, 1. Biomater. Sci. 2021, 9, 663.). Thus, the developed purification system would reduce pharmaceutical prices and improve therapeutic efficacy in cell transplantation therapy.

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Pharmaceutics


Professor TOMI

Professor: TOMI Masatoshi

Associate Professor: NISHIMURA Tomohiro

Assistant Professor: NOGUCHI Saki

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Pharmaceutics is a discipline to pursue the optimal delivery of drug substance to target site of patient's body through the best scientific knowledge and technology, so that patients are released from diseases and disorders. The ultimate goal of our research is "Individualized Pharmaceutical Care".

For realizing such an object, two projects are currently carried out ;

  1. Molecular mechanisms of drug transport across the blood-placental barrier
    The transport process across the blood-placental barrier is a key determinant of fetal drug disposition. The elucidation of placental transport mechanism will provide molecular basis for the individual optimization of drug administration to expectant mothers in more-successful and strategic manner. The blood-placental barrier is formed by syncytiotrophoblasts. Conditionally immortalized syncytiotrophoblast cell lines, TR-TBTs were established in our laboratory. We have elucidated mechanisms of placental transport of several drugs, such as zidovudine and didanosine. These nucleoside analog reverse transcriptase inhibitors (NRTIs) are used for preventing the transmission of HIV from infected pregnant mothers to their fetuses.
  2. Development of various tools for best utilization of drug information, especially, those of OTC therapy. We have developed a manual and an e-learning system of OTC (Over-the-Counter) medicines. These products are now available to public and are used at community pharmacies for guidance to patients.

Students to be welcomed are those who have interest in pharmaceutics and its clinical application. During the stay at our laboratory, students will acquire a vast knowledge of pharmaceutics and its meaningfulness for better clinical drug use. Through collaboration with other research units, students will have the opportunity to brush up their skills of international communication.

http://www.keio-yakuzai.jp 外部リンク

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Clinical Physiology and Therapeutics


Professor HATTORI

Professor: HATTORI Yutaka

Associate Professor: MATSUSHITA Maiko

Assistant Professor: ICHIKAWA Daijyu

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Our laboratory is aiming at conquest of therapy-resistant cancer by means of translational research. For example, multiple myeloma which is a incurable and fatal hematological malignancy despite of application of stem cell transplantation or novel therapy including thalidomide, its derivatives and bortezomib, a dipeptide boronic acid analogue showing inhibition of 26S proteasome. Thus, we are challenging to develop more effective and much safer pharmacotherapy than current ones to overcome refractory cases by designing new drugs under elaboration of our original biological techniques and by conducting clinical trials. We also are trying to identify the targeting molecule of those novel drugs by unique molecular cloning system. Glycobiology, is another important theme in our laboratory. For example, M-proteins produced by myeloma cells revealed a different glycosylation pattern from normal immunoglobulin. It is expected that glycosylation of M-protein will be a novel biomarker for this disease indicating disease control. Future direction is to accumulate preclinical data for conducting clinical trial of the drugs. To accomplish these project, we are conducting a collaborative research with departments of Faculty of Science & Technology and School of Medicine, Keio University, and also some other Universities and academic institutions outside of Keio University. We are also trying to develop the effective immunotherapy using peptides derived from tumor antigens. We are now investigating immunogenesity of novel tumor antigens, which we have identified from leukemia cells and melanoma cells. Our goal is to apply these antigens to peptide vaccination for cancer patients.

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Pharmacotherapeutics


Professor SAITO

Professor: SAITO Yoshimasa

Associate Professor: MATSUZAKI Juntaro

Senior Assistant Professor: KIMURA Masaki

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Our research targets are mainly on metabolic diseases necessary for keeping our homeostasis, especially on the diseases of gastroenterology, liver, muscle, adipose tissues and also cancers. Recently, we focus on epigenetics and microRNAs in the understanding of mechanism in these diseases. Our goal is to develop new therapeutic strategies for these diseases and we always think about the bench-to-bed utility. Our laboratory is always open to everyone who has a high motivation to create a new concept of pharmacotherapeutics. If you have interested in our department, why not join us?

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Clinical Pharmacokinetics


Professor OHTANI

Professor: OHTANI Hisakazu

Senior Assistant Professor: AKIYOSHI Takeshi

Assistant Professor: IMAOKA Ayuko

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The educational target of our laboratory is to turn out researchers and pharmacists who have wide range of pharmaceutical view and knowledge, and is able to solve various clinical problems in pharmaceutical care. We consider that a good practitioner should be able to systematically organize a wide range of pharmaceutical knowledge and such ability can be acquired during pharmaceutical research.
Therefore, our research field is clinical pharmacy based on a variety of fields such as pharmacokinetics, pharmacodynamics, cell biology, information technology, and others. Especially, we aim to solve clinical problems, as mentioned below, for marketed drugs to create pharmaceutical evidences for proper and effective use of medicines.

  1. Study on drug metabolism and drug interactions to promote personalized pharmacotherapy.
  2. Quantitative prediction and IVIVE (in vitro-to-in vivo extrapolation) of drug interactions in drug absorption process.
  3. In vivo PK/PD study for dosage optimization to reduce adverse reactions.
  4. Optimization of pharmacotherapy by using the information technology and pharmacometrics

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Drug Informatics

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Professor HORI

Professor: HORI Satoko

Associate Professor: HASHIGUCHI Masayuki

Assistant Professor: KIZAKI Hayato

Drug information based on sciences and reliable clinical evidences is required for proper use of drugs. On the other hands, there is a tendency of "information overflow", even on a single drug, in different style, quality and quantity.
The objective of our laboratory is to explore the mean and way for rational and proper use of drug information so that medical professionals can give patients evidence-based, safe, and effective drug therapy. The areas of our research covered are information retrieval, critical appraisal, effective provision, and the application of information, etc.

Following research projects are currently ongoing;

  1. Methodology for the proper and effective provision of OTC drug information,
  2. Systematic reviews and network meta-analysis of pharmacotherapy and dietary supplements,
  3. Pharmacoecomics study, e.g., cost-effective analysis of switch OTCs and lifestyle-related diseases, comsumer's perception on payment, etc.
  4. Pharmacoepidemiology study, e.g., development of a reporting system of spontaneous adverse events by patients and consumers
  5. Pharmacogenetics/genomics of methotrexate and warfarin, etc.

Students joining to our research group are expected to acquire the research oriented way of thinking and proper insight on quality information of drugs. We expect that students will be able to play an active role in clinical fields, the pharmaceutical industry, and the government and the related organization after graduation.
Students to be welcomed are, such as, those with interest in proper and effective usage of drugs in clinical phase.

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Pharmacodynamics


Professor MATSUMOTO

Professor: MATSUMOTO Kazuaki

Associate Professor: TAGUCHI Kazuaki

Assistant Professor: ENOKI Yuki

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"Establishment of New Pharmacotherapy Options Based on Drug Efficacy Evaluation and Adverse Event Analysis"

The Division of Pharmacodynamics conducts research, aiming to establish new pharmacotherapy options by evaluating drug efficacy or the therapeutic and adverse effects of drugs.

To maximize their effectiveness while avoiding related adverse events as much as possible, the division analyses influencing factors, and clarifies optimal drug options and administration methods for each patient.

It also establishes new treatment methods by identifying new drug activities and developing new dosage forms. Furthermore, with a view to obtaining evidence that is useful for medical services, it identifies issues to be addressed (such as drug-drug interactions), and expands clinical and basic research.

The division aims to nurture clinical pharmacists to truly contribute to medical services and researchers with the ability to develop drugs needed in such services through research activities.

Figure. Voriconazole (VRCZ) trough concentration and logistic regression model for hepatotoxicity.

The estimated probability of hepatotoxicity at VRCZ trough concentrations of 2mg/L and 4mg/L was 1.6% and 21.6%, respectively



Figure. Relationships for Acinetobacter baumannii ATCC 19606 between the log10CFU/thigh at 24 h and the pharmacokinetic/pharmacodynamic indices.

Sulbactam showed time-dependent bactericidal activity, and was sufficiently bactericidal when an fT>MIC of >60% against A. baumannii thigh infection was achieved.

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Drug Development and Regulatory Science


Professor URUSHIHARA

Professor: URUSHIHARA Hisashi

Associate Professor: HARA Azusa

Every pharmaceutical product is subject to be registered and regulated under appropriate legislation because of its possible serious effects on human lives.
Then, question becomes what kind of data is required, why and when. How to collect such data and how to adequately evaluate are also essential factors to be clarified before starting of drug development process or, even whole life span of a drug.
Establishment of adequate and safe use of the drug in our real world is also crucial point to meet the expectation of patients and medical professions.
All the above issues consist of regulatory sciences and this laboratory is concentrating in clarifying and responding on these questions in accordance with scientific approach and international manner.
Our goal is not easy to be met particularly in the days of such a rapid progress in the human life science can be seen but therefore it is absolutely needed for regulatory sciences to catch up with it.
Students here will be exposed and gain such sciences through study and learning.

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Education Research Center for Pharmaceutical Sciences


Professor SUZUKI

Professor: SUZUKI Takeshi

Associate Professor: ISHIKAWA Satoko

Associate Professor: AIZU-YOKOTA Eriko

Assistant Professor: GONDA Ryoko

The responsibility of our group is to give undergraduate students the training of fundamental chemistry or biology for pharmaceuticals and pharmacy, such as analytical chemistry, pharmacology, biochemistry, hygiene chemistry and organic chemistry, so that students in Faculty of Pharmacy can have the ability to comprehend the modern and progressing life sciences. We are also responsible for managing the introductory and fundamental laboratory training at our Faculty of Pharmacy. We develop the program for laboratory experiment and execute it for undergraduate students during their second and third year.
In parallel, our group is active in conducting research within the above premise. Our current research subjects are;

  1. analysis of reactive oxygen species
  2. explore novel diagnostic and therapeutic approach for intractable neuronal diseases, cardiovascular diseases and inflammation
  3. discover novel substances for therapeutic use for these diseases/disorders
  4. regulation of drug metabolizing enzymes
  5. Application of effective e-learning in pharmacy education
  6. development of effective interprofessional education for pharmaceutical students in Japan
  7. biochemical analysis of pathogenic mechanism in allergic inflammation

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Center for Social Pharmacy and Pharmaceutical Care Sciences

Director: NAKAMURA Tomonori

Division of Pharmaceutical Care Sciences


Professor NAKAMURA

Professor SUZUKI

Professor SUZUKI

Professor: NAKAMURA Tomonori

Professor: SUZUKI Sayo

Senior Assistant Professor: KAWAZOE Hitoshi

Assistant Professor: JIBIKI Aya

Assistant Professor: YOKOYAMA Yuta

Division of Social Pharmacy

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Professor YAMAURA

Professor: YAMAURA Katsunori

Senior Assistant Professor: FUJIMOTO Kazuko

Senior Assistant Professor: KOBAYASHI Noriko

Senior Assistant Professor: IWATA Hiroki

In 2001, Center for Pharmacy Practice was established with the purpose of excellence in medical pharmacy education and nurturing pharmacists who can contribute to the medical front. The early exposure program in a hospital and a community pharmacy run shortly after admission, the four-week practical training in a hospital and the two-week in a pharmacy were made compulsory ahead of other universities. These practical programs have made contribution to improving the motivation pharmacy students should have and keeping it up. The center also plays a central role in the "6-year education program in pharmacy" launched in 2006 with cooperating with many other medical facilities. In addition to enriching the early on-site training, the early pharmacy practical training in the second year focusing on dispensing, the lectures preparing for following practical training in the fourth year, and hands-on clinical session at full scale of hospitals and pharmacies for 11 weeks each are smoothly offered in Center for Pharmacy Practice.

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Basic Education in Arts and Sciences

Professor: FOSTER J PatricK

Associate Professor: UEMURA Ryoutaro

Associate Professor: INOUE Kae

Our group is responsible for a general education curriculum necessary for professionals in human sciences and pharmaceuticals. Each professor covers the disciplinary area which he himself majors in. Students have chances to take the training either by attending a course or joint academic work with each professor.

Each professor is in charge of the following academic activities;

  1. One of my cultural activities is writing critical essays and reviews for several theater magazines and newspapers. In recent years, I am concerned with
    interprofessional education (IPE) and participated in establishing the Japan Association for Interprofessional Education. (Y. E.) ;
  2. I am most interested in immigration and its history and literature, especially in Japanese-Americans. Field work is also contained in my activities. I have published six translations in the past three years. 1. Shigeo Shimada, A Stone Cried Out, 2. James Walvin, The Trader, The Owner, and The Slave, 3. Gordon S. Wood, The Americanization of Benjamin Franklin, 4. Emmy E. Werner, A Conspiracy of Decency-Danish Jews during WWII, 5. Joan Didion, The Year of Magical Thinking, 6. Joan Didion, Blue Nights
  3. I am a physicist, and I have devised physical and mathematical model of radioactive decay, and of chemical kinetics and pharmacokinetics; for example, hypothetical and actual hydrodynamic models about the kinetics. (S. S.).
  4. I study about the ergodicity of some measure preserving transformations.
    I studied the ergodicities of "piecewise rotations", "interval exchanges" and "zippered rectangles", and try to clarify these relations now.

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Laboratory for Radiopharmaceutical Chemistry

Senior Assistant Professor: MORITA-MURASE Yuko

Development of methods for determining the environmental radionuclides, and study evaluating the effect of environmental radiation on the human body.

In the environment, not only natural radionuclides such as radon, but also trace amounts of radionuclides resulting from nuclear testing in the past are present. On the other hand, radiation has been used in medical treatment. Furthermore, small amount of radiation is emitted from some product containing minerals.

To date, we have developed accurate methods for measuring radon and applied successfully to the determination of the radon activity in natural water and indoor air, and presented the resultant distribution of radon in natural water and indoor air. Further work to establish the suitable system for measuring the radionuclide in the outdoors is in progress. Based on the modified measuring system, we measure the radionuclide in various kinds of food and products, and estimate the absorbed dose due to the environmental radionuclide, and the effect of environmental radiation on the human body.

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Hospital Pharmacy Science

Associate Professor: AOMORI Tohru

Assistant Professor: ISHIKAWA Haruki

Hospital Pharmacy Science is close to clinical work.

Faculty members of our lab are active pharmacists holding the posts and duties of the hospital pharmacy. Keio University hospital and the department of pharmacy are the main fields of our activities.

Our mission is to train future leaders of pharmacists.

We aim at the training of future leaders of pharmacists who can play an active part in the healthcare setting. The future leaders of pharmacists need to have research abilities to produce evidence by oneself as well as advanced clinical skills. We nurture these abilities through research activities. The experience in clinical work and clinical research at Keio University Hospitals is useful not only for hospitals and pharmacies but also for pharmaceutical companies.

The clinical sites are full of the research theme.

In order to improve a pharmacotherapy and offer more effective and safer medical care to the patient, we develop the clinical studies that cooperated with the hospital pharmacy and clinical departments.The findings of research provided by pharmacoepidemiology and clinical pharmacology are returned to patients.

Our research themes are ...

  • To build the evidence of pharmacist's work. ・ The impact of the patient compliance instruction by a pharmacist to the therapeutic effect. ・ Establishment of the countermeasure against an exposition of anticancer agent at the time of preparation and administration.
  • Pharmacoepidemiology. ・ Epidemiological study on the cost effectiveness of expensive drugs. ・ Benefit risk evaluation by using data bases
  • Individualization of pharmacotherapy. ・ Analysis of risk factors of adverse drug reactions using electronic medical recods. ・ Factorial analysis of the individual difference about the clinical response of antirheumatic agents.
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Research Center for Drug Discovery


Professor KIM

Director: MISAWA Hidemi

Professor: KIM Yun-Gi

Project Senior Assistant Professor : AKIYAMA Masahiro

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